Profhilo
Hyaluronic acid bio-remodelling · BAP technique
The original 'injectable moisturiser' remains a top-searched skin treatment in Singapore and the UK.
Search interest: about 1,700 searches a month in Singapore for “profhilo” (Ahrefs, October 2026).
One of the few injectables where 'natural' is built into the design.
Reviewed against the Aesthetics International standard. Category: Injectables.
Does Profhilo work?
Established. One of the few injectables where 'natural' is built into the design. Reasonable evidence for improved hydration, elasticity and fine lines over a few months; little evidence for lift or contour.
- Verdict
- Established Long clinical track record. Results depend on selection and technique more than on the device.
- Evidence base
- 3 PubMed-indexed studies cited below, including randomised trials.
- Suits
- Crepey, dehydrated skin of the face, neck and hands; people wanting quality not shape; first-time injectable patients.
- Not for
- Volume loss or descent. Anyone told it will 'lift'.
- In Singapore
- Registered and widely used in Singapore.
- Category
- Injectables · about 1,700 searches a month in Singapore for “profhilo”
- Reviewed
- 1 October 2026 by Aesthetics International. Revised as evidence and regulation change.
What it is
A high-concentration, stabilised hyaluronic acid injected at five points on each side of the face (the BAP technique), from which it spreads through the tissue. It is not a filler: it is designed to hydrate and improve skin quality rather than add shape.
How it works
Hybrid complexes of high- and low-molecular-weight HA release slowly, drawing water into the dermis and, in laboratory work, prompting fibroblasts and keratinocytes to behave more youthfully. Two sessions a month apart is the standard course, repeated roughly twice a year.
What the evidence says
Reasonable evidence for improved hydration, elasticity and fine lines over a few months; little evidence for lift or contour. Because it is HA, it can be dissolved if needed — a safety advantage over collagen stimulators.
What people are saying
Paraphrased from public discussion on TikTok, Instagram, Reddit and in the press. Not testimonials, and not about any one clinic. Reported in: thetweakmentsguide.com, thetweakmentsguide.com.
What the studies show
- RCT
In a triple-blind randomised trial, treatment reduced wrinkle and pore measurements, but dermal thickness did not improve beyond placebo and satisfaction was moderate.
Effects of Profhilo® Tissue Bioremodeling on Skin Texture and Perioral Wrinkles: A Randomized Controlled Triple-Blind Clinical Trial. — Aesthetic Plast Surg, 2026. PMID 41731228.
- cohort
Manufacturer post-marketing surveillance over nearly a decade reported a low rate of adverse events, mostly transient injection-site reactions.
Hyaluronic Acid Hybrid Cooperative Complexes Nearing 10 Years of Use: Update on Safety Assessment Based on Post-Marketing Surveillance Data. — J Cosmet Dermatol, 2025. PMID 40654100.
- review
A review of laboratory and clinical data described improvements in hydration and elasticity, noting that most clinical studies are small and often industry-linked.
Hybrid Cooperative Complexes of Low- and High-Molecular-Weight Hyaluronic Acid in Aesthetic Medicine. — Pharmaceuticals (Basel), 2025. PMID 41599673.
Studies are selected for relevance and quality, not for agreement with the verdict; PubMed records are linked so the reader can check them.
Who it suits
Suits
Crepey, dehydrated skin of the face, neck and hands; people wanting quality not shape; first-time injectable patients.
Not for
Volume loss or descent. Anyone told it will 'lift'.
Alternatives
The two reviewed treatments most often weighed against Profhilo, on the same standard.
| Profhilo | Skin boosters | PDRN and polynucleotides | |
|---|---|---|---|
| Verdict | Established | Established | Established |
| What it is | A high-concentration, stabilised hyaluronic acid injected at five points on each side of the face (the BAP technique), from which it spreads through the tissue. | Micro-injections of hyaluronic acid, sometimes with vitamins, amino acids and antioxidants, placed superficially across the face to hydrate and improve texture and glow. | Polynucleotides are DNA fragments, usually purified from salmon or trout gonads, injected into the dermis in micro-droplets. |
| Evidence base | 3 PubMed-indexed studies cited below, including randomised trials. | 3 PubMed-indexed studies cited below, including randomised trials. | 3 PubMed-indexed studies cited below, including systematic reviews, randomised trials. |
| Suits | Crepey, dehydrated skin of the face, neck and hands; people wanting quality not shape; first-time injectable patients. | Dull, dehydrated skin; make-up that settles into fine lines; neck and décolletage. | Thin, crepey under-eye skin; dull, inflamed or acne-prone skin; post-procedure recovery; people who want quality rather than volume. |
| In one line | One of the few injectables where 'natural' is built into the design. | Dull skin is a collagen problem — boosters hydrate the surface while collagen work happens underneath. | The injected courses are a sensible part of a skin plan; the salmon-sperm facial is mostly the microneedling doing the work. |
Risks
Bumps at the injection points for a day or two, bruising, rare swelling.
In Singapore
Registered and widely used in Singapore. Newer 'Profhilo Structura' targets superficial fat compartments and is a different product.
“One of the few injectables where 'natural' is built into the design.”
Vetted protocols on the same problem
Questions
Is Profhilo a filler?
How long does it last?
Profhilo or skin boosters?
Cite this review
Aesthetics International (2026). Profhilo: does it work? Evidence, risks and verdict. https://aesthetics-international.org/treatments/profhilo/ (reviewed 1 October 2026).
Editorial, unpaid and independent of any manufacturer. Verdict: Established. See what works and what doesn't across all 153 reviews. Spotted an error or a newer study? Suggest a correction — changes are logged on the corrections page. Terms are defined in the glossary.
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